Dr. Naveen K. Khare

Designation:      Reader

Branch:                  Organic Chemistry

Specialization:       Carbohydrates

                                 Natural Products

Date of Birth:        August 17, 1958

Residence:            B 2159, Indiranagar, Lucknow

Phone:                   0522-235-4258       

email:                     nkhare58@gmail.com

Degrees

• Ph.D.,1985, Lucknow University, Lucknow, INDIA

• M.Sc.,1979, Lucknow University, Lucknow, INDIA

• B.Sc.,1977, Lucknow University, Lucknow, INDIA

Positions Held

• Teaching post graduate & undergraduate students at department of chemistry, university of Lucknow, Lucknow- 226007, India since may 1988 – till date.

• On sabbatical for three years as visiting scientist at southern research institute, u.s.a.  since January 1999 to January. 2002.

• Visiting Research Associate with Prof. G. O. Aspinall, department of Chemistry, York University, Toronto, Canada since July 1991 to November 1992.

• Post doctoral fellow with Prof. G. O. Aspinall at department of chemistry, York University, Toronto, Canada since November 1986 to may 1988.

• Post Doctoral Research Associate at Medicinal Chemistry, Central Drug Research Institute, Lucknow, India since October 1984 to October 1986.

Research Interests

• Synthetic carbohydrate chemistry. In USA, was working on a NIH. sponsored project involving design & synthesis of variety of novel target compounds as inhibitors of key enzymes in the mycobacterial cell wall synthesis for the development of potential antitubercular agents. This work involves stereo and regioselective synthesis of di- and oligosaccharide heteroanalogs as potential inhibitors of mycobacterial glycosyl transferases in which the interglycosidic oxygen and/or ring oxygen has been replaced by sulfur.

  Have also worked on the synthesis of complex carbohydrates involving deoxy hexoses, 4,6-pyruvylated hexoses and unusual heptoses of defined configuration found in mycobacteria (especially mais complex ) & campylobacter etc. Each presenting challanges for the development of strategy for stereo and regioselective synthesis of target compounds with careful manipulation of functionality with varying degree of lability. The main objective was to prepare neoglcoconjugates in which the outer sugar residues of the natural antigens are attached to carrier proteins. The  neoglycoconjugates were then characterized for their ability to interact with antibodies to individual strains of mycobacteria & thus give information on the specificities of the antibodies.  The knowledge thus obtained, contribute significantly to our understanding of the immunochemistry of these organisms and may also have practical consequences in the serodiagnosis of bacterial infection.  This work is evident by the list of publications.

  Secondly, was also engaged in the development of synthetic methods for carbocyclic nucleosides as hypoxanthine guanine phospho ribosyl transferase (hgprt) inhibitors present in pathogenic organisms that cause opportunistic infections in hiv/aids. These compounds are not only difficult to handle but also involve a tedious route in multistep synthesis. Also, pursued the synthesis of complex heterocyclic target compounds derived from natural products as selective ligands for the opioids receptors of the central nervous system. This research is directed toward the discovery & development of new ligands possessing potent analgesic activity devoid of the side effects that are associated with currently available drugs for the treatment of chronic pain.